Rat LTBR Protein (His Tag)

20.04.2012

Produkt-Information von LTBR Protein

Synonym	LTBR
Protein Construction	A DNA sequence encoding the rat LTBR (NP_001008316.1 ) extracellular domain (Met 1-Ala 218) was expressed, fused with a polyhistidine tag at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von LTBR Protein

Purity	> 96 % as determined by SDS-PAGE	SDS-PAGE: LTBR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 28
Molecular Mass	The recombinant rat LTBR comprises 202 amino acids and predicts a molecular mass of 23 kDa. The apparent molecular mass of the ratLTBR is approximately 35 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

LTBR Protein Usage Guide

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von LTBR Protein

LTBR (lymphotoxin beta receptor (TNFR superfamily, member 3)) contains 4 TNFR-Cys repeats and belongs to the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. It is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. LTBR has been shown to interact with diablo homolog and TRAF3. It can lead to the release of the cytokine interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release. It specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells.

References

Summers deLuca L. et al., 2011, Proc Natl Acad Sci. 108 (5): 2046-51.
Bista P. et al., 2010, J Biol Chem. 285 (17): 12971-8.
Xu Y. et al., 2011, Biochem Biophys Res Commun. 404 (4): 1060-4.

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