Rat IL1R2 / IL1RB / CD121b Protein (His Tag)

Produkt-Information von IL1R2 / IL1RB / CD121b Protein

QC Testing von IL1R2 / IL1RB / CD121b Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: IL1R2 / IL1RB / CD121b protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 14
Molecular Mass	The recombinant rat IL1R2 comprises 353 amino acids and predicts a molecular mass of 39.7 kDa. The apparent molecular mass of the rat IL1R2 is approximately 55-60 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL1R2 / IL1RB / CD121b Protein

Verwandte Produkte & Themen von IL1R2 / IL1RB / CD121b Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-1R2/ CD121b

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-1 Superfamily and IL-1R/TLR Family>>IL-1R2/ CD121b

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> IL-1R2/CD121b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>IL-1R2/CD121b

Beschreibung von IL1R2 / IL1RB / CD121b Protein

The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). A closely related receptor-like chain IL1R accessory protein (IL1RAcP) has been reported to heterodimerize with the IL1RI to form the signal transduction complex which appears to mediate all the known IL1 signal processes. IL1RII structurally consisting of a ligand binding portion comprised of three Ig -like domains, a single transmembrane region, and a short cytoplasmic domain, is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Like the IL1RI, the human IL1RII can bind all three forms of IL1 (IL1 alpha, IL1 beta and IL1ra) but does not transmit IL1 signals. In addition to the membrane-bound form, IL1RII also exists as the soluble form, and either acts as a decoy receptor that inhibits IL1 action by blocking the binding of IL1 to the type I? receptor complex. Furthermore, IL4 is reported to antagonize the activity of IL1 by inducing the expression and release of this cytokine. Recombinant soluble IL1RII is thus a potent antagonist of IL1 action, and serves as a potential therapeutic target.

References

1. McMahan CJ. et al., 1991, EMBO J. 10: 2821-32.
2. Liu C. et al., 1996, J Biol Chem. 271: 20965-72.
3. Rauschmayr T. et al., 1997, Proc Natl Acad Sci. 94: 5814-19.
4. Neumann D. et al., 2000, J. Immunol. 165: 3350-7.
5. Colotta F. et al., 1993, Science. 261: 472-5.

Sino Biological Inc. liefert Rat IL1R2 / IL1RB / CD121b Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat IL1R2 / IL1RB / CD121b Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/IL1R2-IL1RB-CD121b-Protein-g-9072.html