Rat IL18R1 Protein

Produkt-Information von IL18R1 Protein

QC Testing von IL18R1 Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: IL18R1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 18
Molecular Mass	The recombinant rat IL18R1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 550 amino acids and predicts a molecular mass of 62.5kDa. The apparent molecular mass of the rat IL18R1/Fc monomer is approximately 105 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL18R1 Protein

Verwandte Produkte & Themen von IL18R1 Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-1 superfamily and IL-1R/TLR family >>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>IL18R1/IL-1Rrp/CD218a

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL18R1/IL-1Rrp/CD218a

Beschreibung von IL18R1 Protein

The interleukin-18 receptor 1 (IL18R1), also known as CDw218a (cluster of differentiation w218a), is a cytokine receptor that belongs to the interleukin 1 receptor family, and a single-pass type I membrane protein contining three Ig-ike C2-type domains within the ECD. It specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction, and it is reported that binding to the agonist leads to the activation of NF-kappa-B. IL-18 receptor was first described in 1989. It induces synthesis and release of IFN-gamma, IL- 8, 4 and 13, TNF-alpha and granulocyte/macrophage colony stimulating factor (GM-CSF). It modulates the function of many immunocompetent cells including macrophages, monocytes, lymphocytes and granulocytes. Another feature of IL-18 receptor is its ability to induce apoptosis of many cell types by inducing Fas ligand and receptor, aas well as granzymes. High level of IL18R1 expression is detected in Hodgkin's disease cell lines.

References

1. Dale M. et al., 1999, Genomics. 57(1): 177-9.
2. Sergi B. et al., 2004, J Biol Regul Homeost Agents. 18 (1): 55-61.
3. Wereszczy ska SU. et al., 2004, Pol Merkur Lekarski.16 (93): 279-81.

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