Rat EDAR Protein

Produkt-Information von EDAR Protein

QC Testing von EDAR Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: EDAR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 27
Molecular Mass	The secreted recombinant rat EDAR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 402 amino acids and predicts a molecular mass of 44.4 kDa. The apparent molecular mass of the ratEDAR/Fc monomer is approximately 60-70 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EDAR Protein

Verwandte Produkte & Themen von EDAR Protein

Immunology>>Cytokine & Receptor>>TNF Superfamily>>EDAR

Beschreibung von EDAR Protein

Tumor necrosis factor receptor superfamily member EDAR, also known as Anhidrotic ectodysplasin receptor 1, Ectodysplasin-A receptor, Ectodermal dysplasia receptor, Downless homolog, EDAR and DL, is a single-pass type I membrane protein which contains one death domain and three TNFR-Cys repeats. EDAR / DL is a receptor for EDA isoform A1, but not for EDA isoform A2. It mediates the activation of NF-kappa-B and JNK and may promote caspase-independent cell death. EDAR / DL is detected in fetal kidney, lung, skin and cultured neonatal epidermal keratinocytes. It is not detected in lymphoblast and fibroblast cell lines. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic which is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Defects in EDAR are also the cause of ectodermal dysplasia type 3 (ED3) which is an autosomal dominant condition characterized by hypotrichosis, abnormal or missing teeth, and hypohidrosis due to the absence of sweat glands.

References

1. Koppinen P. et al., 2001, Exp Cell Res. 269 (2): 180-92.
2. Fessing MY. et al., 2006, Am J Pathol. 169 (6): 2075-84.
3. Drew CF. et al., 2007, Dev Biol. 305 (1): 232-45.
4. Fujimoto A.et al., 2008, Hum Mol Genet. 17: 835-43.
5. Kimura R. et al., 2009, Am J Hum Genet. 85 (4): 528-35.

Sino Biological Inc. liefert Rat EDAR Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat EDAR Protein lesen Sie bitte: http://www.sinobiological.com/EDAR-Protein-g-9073.html