Rat EFNB2 / EphrinB2 Protein (His Tag)

Produkt-Information von EFNB2 / EphrinB2 Protein

QC Testing von EFNB2 / EphrinB2 Protein

Purity	> 99 % as determined by SDS-PAGE	SDS-PAGE: EFNB2 / EphrinB2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Arg 29
Molecular Mass	The recombinant rat EFNB2 comprises 212 amino acids and has a predicted molecular mass of 23.5 kDa. The apparent molecular mass of the protein is approximately 33-39 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EFNB2 / EphrinB2 Protein

Verwandte Produkte & Themen von EFNB2 / EphrinB2 Protein

Neuroscience>>Axon Guidance>>Ephrin & Eph Receptor>>Ephrin-B2/EFNB2

Cancer>>Growth Factor & Receptor>>Ephrin & Eph Receptor>>Ephrin-B2/EFNB2

Beschreibung von EFNB2 / EphrinB2 Protein

The ephrins (Eph) and Eph receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosyl- phosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. All ephrins share a conserved extracellular sequence, which most likely corresponds to the receptor-binding domain. This conserved sequence consists of approximately 125 amino acids and includes four invariant cysteines. The cytoplasmic domains are approximately 80 amino acids long and are highly conserved, especially the last 33 amino acids. In molecular biology, ephrins and Eph receptors are components of cell signaling pathways involved in animal development, and implicated in some cancers. Eph receptors are classified as receptor tyrosine kinases (RTKs), and form the largest sub-family of RTKs. Almost all Eph receptors are expressed during various well defined stages of development in assorted locations and concentrations. Ephrin-B2 is a member of the ephrin ligand family, which binds members of the Eph receptor family. It has been shown to bind EphA4, EphB1, EphB2, EphB3, and EphB4. Ephrin-B2 plays a role in a variety of developmental processes, including arterial-venous differentiation, neural crest cell migration, and axon guidance.

References

1. Cerretti DP. et al., 1995, Mol Immunol. 32 (16): 1197-205.
2. Gale NW. et al.,1996, Neuron.17 (1): 9-19.
3. Flanagan J. et al., 1998, Annual Review of Neuroscience. 21: 309-45.
4. Holder N. et al., 1999, Development. 126 (10): 2033-44.
5. Wilkinson DG. et al., 2001, Nat. Rev. Neurosci. 2 (3): 155-64.
6. Murai KK. et al., 2003, Journal of Cell Science. 116: 2823-32.

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