Rat IL17RA / IL17R Protein (His Tag)

Produkt-Information von IL17RA / IL17R Protein

QC Testing von IL17RA / IL17R Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL17RA protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 32
Molecular Mass	The recombinant rat IL17RA comprises 300 amino acids and predicts a molecular mass of 34.1 kDa. The apparent molecular mass of  the recombinant protein is approximately 52-58 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL17RA / IL17R Protein

Verwandte Produkte & Themen von IL17RA / IL17R Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-17 Family & IL-17 Receptor Family>>IL-17R/IL-17RA/CD217

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>IL-17R/IL-17RA/CD217

Beschreibung von IL17RA / IL17R Protein

Interleukin-17 receptor A, also known as IL-17 receptor A, IL-17RA, IL17RA and IL17R, is an ubiquitous type I  membrane glycoprotein that binds with low affinity to interleukin 17A (IL17A). IL17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. IL17A binds to a type I  cell surface receptor called IL17R of which there are at least three variants IL17RA, IL17RB, and IL17RC. IL17RA is a widely expressed glycoprotein that plays a central role in inflammatory responses. IL17R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The aa sequence of mouse IL17RA is 69% identical to the human IL17R. Within the extracellular domain, mouse IL17RA shares 72% aa sequence identity with human IL17RA. IL17RA associates with IL17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL17RA ligation promotes T cell activation and the production of IL-6, G-CSF, SCF, and multiple proinflammatory chemokines.

References

1. Yao Z. et al., 1997. Cytokine. 9 (11): 794-800.
2. Schwander R. et al., 2000, J Exp Med. 191:1233-40.
3. Starnes T. et al., 2002, J Immunol. 169 (2): 642-6.
4. Toy D. et al., 2006, J Immunol. 177 (1): 36-9.
5. Takahashi N. et al., 2008, J Exp Med. 205 (8): 1755-61.
6. Smith E. et al., 2008, J Immunol. 181 (2): 1357-64.

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