Rat IL-21R / Interleukin-21 Receptor Protein (His Tag)

Produkt-Information von IL-21R / Interleukin-21 Receptor Protein

QC Testing von IL-21R / Interleukin-21 Receptor Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: IL-21R protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 20
Molecular Mass	The recombinant rat IL21R comprises 228 amino acids and predicts a molecular mass of 26.5 kDa. The apparent molecular mass of  the recombinant protein is approximately 43-48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL-21R / Interleukin-21 Receptor Protein

Verwandte Produkte & Themen von IL-21R / Interleukin-21 Receptor Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-21R/IL21R

Beschreibung von IL-21R / Interleukin-21 Receptor Protein

Interleukin-21 receptor, also known as IL-21 receptor, IL-21R, Novel interleukin receptor, IL21R and NILR, is a single-pass type I  membrane protein which belongs to the type I  cytokine receptor family and Type 4 subfamily. The WSXWS motif of IL-21R appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding. The box 1 motif of IL-21R is required for JAK interaction and / or activation. The IL-21R is discovered as a novel member of the class-I-cytokine-receptor family and is selectively expressed in lymphoid tissues. IL-21R shows strong sequence homologies to the interleukin-4 receptor alpha chain gene ( IL-4RA ). Interleukin-21 ( IL-21 ) belongs to a family of cytokines that bind to a composite receptor consisting of a private receptor ( IL-21R ) and the common cytokine receptor gamma chain ( gamma(C) ). The IL-21R is widely distributed on lympho-haematopoietic cells and IL21 impacts a number of cell types, including CD8+ memory T cells, NK cells and subsets of CD4 memory T cells. Increased IL21 production is characteristic of certain autoimmune diseases and is likely to contribute to autoantibody production as well as pathological features of autoimmune disease. The critical role of IL21 in promoting humoral immune responses makes it an important focus of potential therapeutic interventions in conditions characterised by overproduction of pathogenic autoantibodies.

References

1. Hecker,M. et al., 2003, Genes Immun. 4?(3): 228-33.
2. Ettinger, R. et al., 2008, Ann Rheum Dis. 67 Suppl 3?:iii 83-6.
3. Fr?hlich, A. et al., 2009, Science. 324?(5934): 1576-80.
4. Webb, R. et al., 2009,?Arthritis Rheum. 60?(8): 2402-7.

Sino Biological Inc. liefert Rat IL-21R / Interleukin-21 Receptor Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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