Rat IL13RA2 / IL13R Protein (His Tag)

Produkt-Information von IL13RA2 / IL13R Protein

QC Testing von IL13RA2 / IL13R Protein

Purity	> 85 % as determined by SDS-PAGE	SDS-PAGE: IL13RA2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 24
Molecular Mass	The recombinant rat IL13RA2 comprises 324 amino acids and predicts a molecular mass of 37.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 44 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL13RA2 / IL13R Protein

Verwandte Produkte & Themen von IL13RA2 / IL13R Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-13RA2/CD213a2

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-13RA2/CD213a2

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL-13RA2/CD213a2

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>IL-13RA2/CD213a2

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IL-13RA2/CD213a2

Beschreibung von IL13RA2 / IL13R Protein

Interleukin-13 receptor alpha2 chain(IL-13Rα2) is one of the receptor components for IL-13, a Th2 cell-derived pleiotropic immune regulatory cytokine. IL13Rα2 contains 3 fibronectin type-III domains, and binds as a monomer with high affinity to IL-13. IL-13Rα2 exists both on the cell membrane and in soluble form intracellularly which are generated from distinct transcripts. IL-13Rα2 was initially cloned from a kidney cell line and then found to be expressed in brain, spleen, liver, thymus, and also in the bone marrow, which are hemopoietic or hypervascular tissues. Soluble IL-13Rα2 was found in multiple mouse organs and was up-regulated in lungs following allergen challenge. IL-13Rα2 is expressed on certain types of cancer cells including glioblastoma, AIDS Kaposi's sarcoma, and head and neck cancer. In a IL13Rα2 transgenic mice model, the antitumor activity of IL13-PE, a receptor-directed cytotoxin was profoundly enhanced, providing elimination of established tumor in some xenografts. Comparisons of the human and murine receptors show that they are structurally conserved, share 59% aa identity.

References

1. Kawakami K. 2005, Curr Gene Ther. 5(2): 213-23.
2. Tabata Y.? et al., 2007, Curr Allergy Asthma Rep. 7(5): 338-45.
3. Yasuhiro T. et al., 2006, The Journal of Immunology. 177: 7905-12.
4. Debra D Donaldson. et al., 1998, The Journal of Immunology. 161: 2317-24.

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