Rat IL10RB / IL10R2 Protein

Sino Biological Inc. liefert Rat IL10RB / IL10R2 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat IL10RB / IL10R2 Protein lesen Sie bitte: http://www.sinobiological.com/IL10RB-IL-10R2-Protein-g-9950.html

Produkt-Information von IL10RB / IL-10R2 Protein

QC Testing von IL10RB / IL-10R2 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: IL10RB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 22
Molecular Mass	The recombinant rat IL10RB/Fc is a disulfide-linked homodimer. The reduced monomer comprises 442 amino acids and has a predicted molecular mass of 50.7 kDa. The apparent molecular mass of the protein is approximately 68 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL10RB / IL-10R2 Protein

Verwandte Produkte & Themen von IL10RB / IL-10R2 Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-10RB/CDw210b

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Monocyte Markers>>IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> IL-10RB/CDw210b

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>> IL-10RB/CDw210b

Beschreibung von IL10RB / IL-10R2 Protein

The functional IL-10 receptor consists of two polypeptide chains, a ligand binding chain IL-10 Rα (IL-10 R1) and a signal transduction molecule known as IL-10 Rβ (IL-10 R2). Both chains of the IL-10 R are expressed on many hematopoietic cells, including lymphocytes, monocytes and neutrophils, with the IL-10 Rβ chain expressed at higher levels than the IL-10 Rα chain in most cases. Interleukin 10 receptor beta (IL-10 Rβ) , also known as CD210b and CRF2-4, is an 80-85 kDa member of the type I I cytokine receptor family of proteins and contains two fibronectin type-III domains. The widely expressed IL-10 Rβ serves as a signal transducing accessory chain not only for IL-10, but also for other interleukins including IL-22, -28A, -28B and -29 (plus IL-26 in human) when complexed to the ligand-binding chains. It has been shown that the action of IL-10 delivered through its receptor can affect a variety of immune functions including inhibition of pro-inflammatory cytokine synthesis and regulation of the growth and function of B cells and antigen presenting cells. The human IL-10 Rβ shares 69% homology to its mouse counterpart in amino acid sequence. Research evidences indicated that defects in IL10RB are associated with susceptibility to hepatitis B virus infection.

References

1. Liu Y. et al., 1994, J Immunol. 152:1821-9.
2. Kotenko SV. et al.,1997, EMBO J. 16 (19): 5894-903.
3. Gibbs VC. et al., 1997, Pennica Gene. 186: 97-101.
4. Kotenko SV. et al., 2001, J Biol Chem. 276: 2725-32.
5. Crepaldi L. et al., 2001, J Immunol. 167: 2312-22.
6. Dinant S. J. et al., 2007, Surg Res. 141 (2): 176-82.