Rat CD2 Protein

04.12.2012

Sino Biological Inc. liefert Rat CD2 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CD2 Protein lesen Sie bitte: http://www.sinobiological.com/CD2-Protein-g-9949.html

Produkt-Information von CD2 Protein

Synonym	CD2
Protein Construction	A DNA sequence encoding the rat CD2 (Q5I0M6) (Met1-Pro202) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von CD2 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: CD2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Arg 23
Molecular Mass	The recombinant rat CD2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 421 amino acids and has a predicted molecular mass of 47.5 kDa. The apparent molecular mass of the protein is approximately 58-64 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von CD2 Protein

Related Areas:

Cancer>>Cancer Stem Cell (CSC)>>CD2

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>CD2

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD2

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>CD2

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD2

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD2	Human	CD2 Protein, Recombinant	10982-H08H
CD2	Mouse	CD2 Protein, Recombinant	50537-M08H
CD2	Rat	CD2 Protein, Recombinant	80158-R02H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human CD2	WB, ELISA	CD2 Antibody (Antigen Affinity Purified)	10982-RP02
Human CD2	WB, ELISA	CD2 Antibody, Mouse MAb	10982-MM06
Mouse CD2	WB, ELISA	CD2 Antibody, Rabbit PAb	50537-RP01
Mouse CD2	WB, ELISA	CD2 Antibody, Rabbit PAb (Antigen Affinity Purified)	50537-RP02
Mouse CD2	WB, ELISA	CD2 Antibody	50537-R029

Beschreibung von CD2 Protein

T-cell surface antigen CD2, also known as T-cell surface antigen T11/Leu-5, CD2, and SRBC, is a single-pass type I membrane protein. It contains one Ig-like C2-type domain and one Ig-like V-type domain. CD2 is a cell adhesion molecule expressed on T cells and is recognized as a target for CD48 (rats) and CD58 (humans). Tremendous progress has been achieved in understanding the function of CD2, the mechanism of molecular recognition and protein folding. CD2 has been shown to set quantitative thresholds in T cell activation. CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48 / BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain of CD2 is implicated in the signaling function. The complex of CD2 and CD58 also plays an important role in enhancing the adhesion of T lymphocytes to target cells, and promoting hyperplasia and activation of T lymphocytes. The expression of CD2 significantly increased with the severity of chronic HBV infection, which suggested that CD2 might contribute to the hepatocyte damage in chronic HBV infection.

References

Bai Y et al., 2002, Am J Transplant. 2 (7): 618-26.
Wilkins A. et al., 2003, Curr Protein Pept Sci. 4 (5): 367-73.
McNerney ME. et al., 2006, Curr Top Microbiol Immunol. 298 : 91-120.
Li J. et al., 2008, Cell Mol Immunol. 5 (1): 69-73.