Rat CD7 Protein

Sino Biological Inc. liefert Rat CD7 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CD7 Protein lesen Sie bitte: http://www.sinobiological.com/CD7-Protein-g-9953.html

Produkt-Information von CD7 Protein

QC Testing von CD7 Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: CD7 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 23
Molecular Mass	The recombinant rat CD7/Fc is a disulfide-linked homodimer. The reduced monomer comprises 368 amino acids and has a predicted molecular mass of 41.1 kDa. The apparent molecular mass of the protein is approximately 48 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD7 Protein

Verwandte Produkte & Themen von CD7 Protein

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> CD7

Beschreibung von CD7 Protein

T-cell antigen CD7, also known as T-cell surface antigen Leu-9, and CD7, is a single-pass type I  membrane protein. It is expressed on human T and NK cells, as well as on cells in the early stages of T, B, and myeloid cell differentiation. CD7 is a T cell-associated antigen which appears early in ontogeny and persists on circulating T cells. It appears to have a significant role in T cell development and function. The precise mechanism by which this molecule mediates its effect is not known. CD7-mediated signals appear to augment function of adhesion molecules on NK cells, which may be involved in NK cell activation by providing both anchorage and costimulatory triggering. The CD7 molecule is a differentiation antigen found on the surface of T lymphocytes and also on a very minor fraction of acute nonlymphocytic leukemia (ANLL). CD7 is highly expressed on malignant immature T cells and is generally absent on malignant mature T cells, such as CD4+ Sezary leukemia and HTLV-1+ adult T-cell leukemia cells. Studies in CD7-deficient mice have provided insights into CD7 function, and demonstrated key roles for CD7 in regulating peripheral T and NK cell cytokine production and sensitivity to LPS-induced shock syndromes.

References

1. Rabinowich H. et al., 1994, J Immunol. 152 (2): 517-26.
2. Leta E. et al., 1995, Cell Immunol. 165 (1): 101-9.
3. Polskj JM. et al., 2000, Leuk Lymphoma. 39 (5-6): 633-9.
4. Stillwell R. et al., 2002, Immunol. Res. 24 (1): 31-52.
5. Murphy M. et al., 2002, Am J Dermatopathol. 24 (1): 6-16.