Rat GHR / Growth Hormone Receptor Protein

27.03.2013

Sino Biological Inc. liefert Rat GHR / Growth Hormone Receptor Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat GHR / Growth Hormone Receptor Protein lesen Sie bitte: http://www.sinobiological.com/Growth-Hormone-Receptor-GHR-Protein-a-734.html

Produkt-Information von GHR / Growth Hormone Receptor Protein

Synonym	GHR
Protein Construction	A DNA sequence encoding the rat GHR (P16310-1) (Met1-Arg265) was expressed with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von GHR / Growth Hormone Receptor Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: GHR protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 19
Molecular Mass	The recombinant rat GHR/Fc is a disulfide-linked homodimer. The reduced monomer comprises 488 amino acids and has a predicted molecular mass of 55.4 kDa. The apparent molecular mass of the protein is approximately 66 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von GHR / Growth Hormone Receptor Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von GHR / Growth Hormone Receptor Protein

Growth hormone receptor, also known as GH receptor, Somatotropin receptor and GHR, is a single-pass type I membrane protein which belongs to the type I cytokine receptor family and type 1 subfamily. GHR contains one fibronectin type-III domain. Growth hormone receptor / GHR is expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 of GHR is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression of GHR in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 of GHR is expressed in lung, stomach and muscle. Growth hormone receptor / GHR is a receptor for pituitary gland growth hormone. It is involved in regulating postnatal body growth. On ligand binding, it couples to the JAK2 / STAT5 pathway. Isoform 2 of GHR up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Defects in GHR are a cause of Laron syndrome (LARS) which is a severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may also be a cause of idiopathic short stature autosomal (ISSA) which is defined by a subnormal rate of growth.

References

Leung DW. et al., 1987, Nature. 330:537-43.
Sobrier M-L. et al., 1997, J Clin Endocrinol Metab. 82: 435-7.
Enberg B. et al., 2000, Eur J Endocrinol. 143: 71-6.
Pantel J. et al., 2000, J Biol Chem. 275: 18664-9.
Jorge AAL. et al., 2004, Clin Endocrinol. (Oxf.) 60: 36-40.