Mouse NCSTN / Nicastrin Protein (His Tag)

Produkt-Information von NCSTN / Nicastrin Protein

QC Testing von NCSTN / Nicastrin Protein

Purity	> 99 % as determined by SDS-PAGE	SDS-PAGE: NCSTN / Nicastrin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 28
Molecular Mass	The recombinant mouse NCSTN comprises 652 amino acids and has a predicted molecular mass of 73 kDa. The apparent molecular mass of the protein is approximately 95-99 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von NCSTN / Nicastrin Protein

Verwandte Produkte & Themen von NCSTN / Nicastrin Protein

Signal Transduction>>Notch Signaling Pathway>>Nicastrin/NCSTN

Stem Cell>>Notch Signaling Pathway>>Nicastrin/NCSTN

Beschreibung von NCSTN / Nicastrin Protein

Nicastrin, also known as NCSTN, is a single-pass type I  membrane protein which belongs to the nicastrin family. Nicastrin was named after the Italian village Nicastro, reflecting the fact that Alzheimer's disease was described in 1963 after studying descendants of an extended family originating in the village of Nicastro that had Familial Alzheimer's Disease (FAD). Nicastrin is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing amyloid precursor protein (APP) to the short Alzheimer's disease-associated peptide amyloid beta. Nicastrin may represent a stabilizing cofactor required for the assembly of the gamma-secretase complex. The other proteins in the complex are presenilin, which is the catalytically active component of the complex, APH-1, and PEN-2. Nicastrin itself is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the complex, all of which undergo significant post-translational modification before becoming active in the cell. Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.

References

1. Feldman RG. et al., 1963, Neurology. 13: 811-24.
2. Satoh J. et al., 2001, Neuropathology. 21: 115-22.
3. Zhang YW. et al., 2005, J Biol Chem. 280 (17): 17020-6.
4. Kaether C. et al., 2006, Neurodegener Dis. 3 (4-5): 275-83.
5. Chi A. et al., 2006, J. Proteome Res. 5: 3135-44.

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