Rat F11R / JAM-A / JAM-1 Protein

Produkt-Information von F11R / JAM-A / JAM-1 Protein

QC Testing von F11R / JAM-A / JAM-1 Protein

Purity	> 96% as determined by SDS-PAGE	SDS-PAGE: F11R protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Lys 27
Molecular Mass	The recombinant rat F11R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 453 amino acids and has a predicted molecular mass of 49.9 kDa. The apparent molecular mass of the protein is approximately 60 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von F11R / JAM-A / JAM-1 Protein

Verwandte Produkte & Themen von F11R / JAM-A / JAM-1 Protein

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>JAM-A/F11R/CD321

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>JAM-A/F11R/CD321

Immunology>>Cluster of Differentiation>>Other>>JAM-A/F11R/CD321

Beschreibung von F11R / JAM-A / JAM-1 Protein

Junctional adhesion molecule A, also known as Junctional adhesion molecule 1, Platelet F11 receptor, JAM-1, Platelet adhesion molecule 1, JAM-A, PAM-1, CD321 and F11R, is a single-pass type I  membrane protein which belongs to the immunoglobulin superfamily and Junctional Adhesion Molecule (JAM) family. JAM-A / CD321 is the firstly identified member of the JAM family comprising at least three members. JAM-A is specifically localized in tight junctions of epithelial and endothelial cells and is involved in the regulation of junctional integrity and permeability by serving as a physical barrier in a homophilic manner. JAM-A is also expressed on the surface of hematopoeitic cells, such as platelets and leukocytes, and acts as a ligand for integrin LFA-1 or a platelet receptor, consequently plays key roles in a variety of cellular processes, including platelet aggregation, leukocyte transmigration, and angiogenesis. In addition, JAM-A has also been implicated in the attachment of reovirus that causes diarrhea.

References

1. Williams LA. et al., 1999, Mol Immunol. 36: 1175-88.
2. Sobocka MB. et al., 2000, Blood. 95: 2600-9.
3. Babinska A. et al., 2002, Thromb Haemost. 88: 843-50.
4. Ostermann G. et al., 2002, Nat Immunol. 3: 151-8.
5. Kenneth J. et al., 2005, J Biol Chem. 280: 11665-74.
6. Bazzoni G. et al., 2003, Curr Opin Cell Biol. 15: 525-30.
7. Barton ES. et al., 2001, Cell. 104 : 441-51.

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