Rat CD52 / CDW52 Protein

25.10.2012

Produkt-Information von CD52 / CDW52 Protein

Synonym	CD52, Cdw52, Rb7
Protein Construction	A DNA sequence encoding the rat ILCD52 (Q63064) (Met1-Ala69) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von CD52 / CDW52 Protein

Purity	> 70 % as determined by SDS-PAGE	SDS-PAGE: CD52 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gly 24
Molecular Mass	The recombinant rat CD52/Fc is a disulfide-linked homodimer. The reduced monomer comprises 287 amino acids and has a predicted molecular mass of 31.4 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD52 / CDW52 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CD52 / CDW52 Protein

CDw52 is a small glycosylphosphatidylinositol (GPI) anchored glycoprotein. It has a mature peptide comprising only 12 amino acids and is abundantly expressed on human lymphocytes. It is also expressed at a high level in the male reproductive system, being found in the epididymis, seminal vesicle, seminal plasma and on the surface of mature (but not testicular) spermatozoa. Its possible transfer from epithelial cells in the epididymis to maturing sperm may represent a novel method of acquisition of cell surface antigens. CDw52 may play a role in carrying and orienting carbohydrate. It is an unusually good target for complement-mediated cell lysis. CDw52 is targeted by alemtuzumab which is an antibody used for the treatment of chronic lymphocytic leukemia and currently being evaluated in a phase III clinical trial for the treatment of multiple sclerosis.

References

Buggins AG. et al., 2002, Blood. 100 (5): 1715-20.
Ratzinger G. et al., 2003, Blood. 101 (4): 1422-9.
Piccaluga PP. et al., 2007, Haematologica. 92 (4): 566-7.

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