Rat BCAM Protein (His Tag)

Produkt-Information von BCAM Protein

QC Testing von BCAM Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: BCAM protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 26
Molecular Mass	The recombinant rat BCAM comprises 529 amino acids and predicts a molecular mass of 58.2 kDa. The apparent molecular mass of  the recombinant protein is approximately 68 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von BCAM Protein

Verwandte Produkte & Themen von BCAM Protein

Cardiovascular>>Red Blood Cell>>BCAM/CD239

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>BCAM/CD239

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>BCAM/CD239

Beschreibung von BCAM Protein

Basal cell adhesion molecule (BCAM) and Lutheran blood group glycoprotein (LU) are two alternatively spliced variants of a single pre-mRNA. They are type I membrane proteins of the immunoglobulin superfamily (IgSF) sharing similar structure characteristics except for the length of cytoplasmic tails. The mature 597 amino acid BCAM contains an extracellular domain composing of five Ig-like domains (two V-set and three C2-set) , a single transmembrane domain, and a 19aa cytoplasmic domain which lacks the putative Src homology 3 (SH3) binding site compared to the 59aa cytoplasmic domain present in LU. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. It has been shown that BCAM expression is upregulated following malignant transformation in some cell types in vivo and in vitro, and BCAM is identified as a marker of epithelial ovarian cancers. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.

References

1. Campbell IG. et al., 1994, Cancer Res. 54: 5761-5.
2. Parsons SF. et al., 1995, Proc Natl Acad Sci. 92: 5496-500.
3. Nemer WE. et al., 2001, J Biol Chem. 276: 23757-62.
4. Nemer WE. et al., 2007, Blood. 109: 3544-51.

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