Rat ErbB3 / HER3 Protein

Sino Biological Inc. liefert Rat ErbB3 / HER3 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat ErbB3 / HER3 Protein lesen Sie bitte: http://www.sinobiological.com/ErbB3-HER3-Protein-g-9882.html

Produkt-Information von ErbB3 / HER3 Protein

QC Testing von ErbB3 / HER3 Protein

Purity	> 80% as determined by SDS-PAGE	SDS-PAGE: ErbB3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 20
Molecular Mass	The recombinant rat ERBB3/Fc is a disulfide-linked homodimer. The reduced monomer comprises 863 amino acids and has a predicted molecular mass of 95.5 kDa. The apparent molecular mass of the protein is approximately 115 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von ErbB3 / HER3 Protein

Verwandte Produkte & Themen von ErbB3 / HER3 Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>HER3/ErbB3

Cancer>>Cancer Biomarkers>>HER3/ErbB3

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>HER3/ErbB3

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>HER3/ErbB3

Beschreibung von ErbB3 / HER3 Protein

ErbB3, also known as Her3 (human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.

References

1. Kraus MH. et al., 1989, Proc Natl Acad Sci. 86: 9193-7.
2. Carraway K.L. et al., 1994, J Biol Chem. 269: 14303-6.
3. Wallasch C. et al., 1995, EMBO J. 14: 4267-75.
4. Alimandi M. et al., 1995, Oncogene. 10: 1813-21.
5. Gamett DC. et al., 1995, J Biol Chem. 270: 19022-7.
6. Katoh M. et al., 1993, Biochem Biophys Res Commun.192: 1189-97.