Canine IL-8 / CXCL8 Protein (Native)

Sino Biological Inc. liefert Canine IL-8 / CXCL8 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Canine IL-8 / CXCL8 Protein (Native) lesen Sie bitte: http://www.sinobiological.com/IL-8-CXCL8-Protein-g-9881.html

Produkt-Information von IL-8 / CXCL8 Protein

QC Testing von IL-8 / CXCL8 Protein

Purity	>95% as determined by SDS-PAGE	SDS-PAGE: IL-8 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ala 23
Molecular Mass	The recombinant canine IL8 comprises 80 amino acids and has a predicted molecular mass of 9.2 kDa. The apparent molecular mass of the protein is approximately 9 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS 0.5mMTCEP PH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL-8 / CXCL8 Protein

Verwandte Produkte & Themen von IL-8 / CXCL8 Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IL-8/CXCL8

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other Interleukin & Receptor>>IL-8/CXCL8

Beschreibung von IL-8 / CXCL8 Protein

Interleukin-8 (IL8), also known as CXCL8, is a member of the CXC chemokine family of small (8–10 kDa) proteins, a subfamily of chemokines within the cytokine superfamily. This chemokine is secreted by a variety of cell types including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, and various tumor cell lines in response to inflammatory stimuli (IL-1, TNF, LPS, etc). IL8 has the N-terminal tripeptide Glu-Leu-Arg (ELR) motif, which is known to mediate IL8 receptor binding and subsequent signal transduction, such as the TRAF6- NF-κB pathway, and involved in inflammatory and allergic responses. Furthermore, it has been shown that IL8 also plays a vital role in angiogenesis which is important for tumorigenesis, progression and metastasis, and accordingly the expression levels of IL8 correlate with disease progression in several human carcinomas. Multiple N-terminal processed forms for this protein are available, and this purified IL8 (6-77 amino acids) is the most prominent one.

References

1. Baqqiolini M. et al., 1992, FEBS Lett. 307: 97-101.
2. Koch A.E. et al., 1992, Science. 258: 1798-1801.
3. Bar-Eli M. et al., 1999, Pathobiology. 67: 12-8.
4. Charalambous C. et al., 2005, Cancer. Res. 65: 10347-54.
5. Manna SK. et al., 2005, J Biol Chem. 280: 7010-21.