Rat CXCL16 / SRPSOX Protein

Sino Biological Inc. liefert Rat CXCL16 / SRPSOX Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von CXCL16 / SRPSOX Protein

QC Testing von CXCL16 / SRPSOX Protein

Purity	>90% as determined by SDS-PAGE	SDS-PAGE: CXCL16 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asn 27
Molecular Mass	The recombinant rat CXCL16/Fc is a disulfide-linked homodimer. The reduced monomer comprises 413 amino acids and has a predicted molecular mass of 46 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CXCL16 / SRPSOX Protein

Verwandte Produkte & Themen von CXCL16 / SRPSOX Protein

Immunology>>Cytokine & Receptor>>Chemokine & Receptor>>CXCL16/SR-PSOX

Beschreibung von CXCL16 / SRPSOX Protein

C-X-C motif chemokine 16, also known as Small-inducible cytokine B16, SR-PSOX, and CXCL16, is a single-pass type I membrane protein which belongs to the intercrine alpha (chemokine CxC) family. It is expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. It is weakly expressed in heart and liver and no expression in brain and bone marrow. CXCL16 is expressed on the surface of APCs including subsets of CD19(+) B cells and CD14(+) monocyte / macrophages, and functional CXCL16 is also shed from macrophages. CXCL16 is an alpha (CXC) chemokine but also has characteristics of CC chemokines and a structure similar to fractalkine (neurotactin) in having a transmembrane region and a chemokine domain suspended by a mucin-like stalk. CXCL16 may function in promoting interactions between DCs and CD8 T cells and in guiding T cell movements in the splenic red pulp. CXCL16 was also found in the thymic medulla and in some nonlymphoid tissues, indicating roles in thymocyte development and effector T cell trafficking.

References

1. Matloubian M. et al., 2000, Nat Immunol. 1 (4): 298-304.
2. Wilbanks A. et al., 2001, J Immunol. 166 (8): 5145-54.
3. Abel S. et al., 2004, J Immunol. 172 (10): 6362-72.