Rat EPCAM Protein

Produkt-Information von EPCAM Protein

QC Testing von EPCAM Protein

Purity	> 98 % as determined by SDS-PAGE	SDS-PAGE: EPCAM protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 24
Molecular Mass	The recombinant rat EPCAM/Fc is a disulfide-linked homodimer. The reduced monomer comprises 484 amino acids and has a predicted molecular mass of 54.8 kDa. The apparent molecular mass of the protein is approximately 61 and 37 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EPCAM Protein

Verwandte Produkte & Themen von EPCAM Protein

Cancer>>Cancer Stem Cell (CSC)>>EpCAM/TROP-1/TACSTD1

Cancer>>Cancer Biomarkers>>EpCAM/TROP-1/TACSTD1

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>EpCAM/TROP-1/TACSTD1

Immunology>>Cluster of Differentiation>>Other>>EpCAM/TROP-1/TACSTD1/CD326

Beschreibung von EPCAM Protein

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. This protein is present in the majority of human epithelial cells and is highly expressed in gastrointestinal carcinomas. It has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. Since the cell-cell adhesion is known to play an important role in tumor progression and metastasis, the high expression of GA733-2 antigen is associated with malignant tumor development in various types of cancer lesions. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. EpCAM is being used as a target for immunotherapy treatment of human carcinomas.

References

1. Simon B. et al., 1990, Proc Natl Acad Sci. 87: 2755-9.
2. Chong JM. et al., 2001, J. Biol. Chem. 276: 5804-13.
3. Litvinov SV. et al., 1994, J Cell Biol. 125: 437-46.
4. Balzar M. et al., 1999. J Mol Med. 77: 699-712.
5. Yamashita T. et al., 2007, Cancer Res. 67: 10831-9.

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