Rat CD47 Protein

Produkt-Information von CD47 Protein

QC Testing von CD47 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: CD47 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 19
Molecular Mass	The recombinant rat CD47/Fc is a disulfide-linked homodimer. The reduced monomer comprises 363 amino acids and has a predicted molecular mass of 40.8 kDa. The apparent molecular mass of the protein is approximately 57-62 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD47 Protein

Verwandte Produkte & Themen von CD47 Protein

Immunology>>Cluster of Differentiation>>CD47

Immunology>>Adhesion Molecule>>CD47

Beschreibung von CD47 Protein

CD47 is a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. CD47 gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. CD47 contains 1 Ig-like V-type (immunoglobulin-like) domain and interacts with THBS1 and fibrinogen. By acting as an adhesion receptor for THBS1 on platelets, CD47 plays a role in both cell adhesion and in the modulation of integrins. It also plays an important role in memory formation and synaptic plasticity in the hippocampus. CD47 is the receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Its interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation.

References

1. Brown EJ. et al., 2001, Trends Cell Biol. 11 (3): 130-5.
2. Oldenborg PA. 2004, Leuk Lymphoma. 45 (7): 1319-27.
3. Kaczorowski DJ. et al., 2007, Circ Res. 100 (5): 602-3.

Sino Biological Inc. liefert Rat CD47 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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