Rat CD55 / DAF Protein

Produkt-Information von CD55 / DAF Protein

QC Testing von CD55 / DAF Protein

Purity	> 82 % as determined by SDS-PAGE	SDS-PAGE: CD55 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asp 35
Molecular Mass	The recombinant rat CD55/Fc is a disulfide-linked homodimer. The reduced monomer comprises 578 amino acids and has a predicted molecular mass of 64.5 kDa. The apparent molecular mass of the protein is approximately 91 and 54 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD55 / DAF Protein

Verwandte Produkte & Themen von CD55 / DAF Protein

Immunology>>Innate Immunity>>Complement System>>CD55/DAF

Immunology>>Cluster of Differentiation>>Other>>CD55/DAF

Beschreibung von CD55 / DAF Protein

CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It interferes with the functions of C3 and C5 convertases in both the classical and alternative pathways by preventing the assembly of the C3bBb complex or accelerating the disassembly of preformed convertase, and thus disrupts the cascade and protects the host cells from damage. Antigens present on the CD55/DAF constitute determinant for the Cromer blood group system. CD55/DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that CD55/DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. There are two variants of CD55 encoded by alternatively spliced transcripts, the predominant variant is a GPI-anchored membrane form ubiquitously expressed on cells exposed to plasma complement proteins, whereas a soluble form present at much lower level.

References

1. Bergelson JM. et al., 1994, Proc Natl Acad Sci. 91: 6245-8.
2. Terstappen LW. et al., 1992, J Leuro Biol. 52: 652-60.
3. Liu J. et al., 2005, J Exp Med. 201: 567-77.
4. Madjd Z. et al., 2004, Clin Cancer Res. 10: 2797-803.
5. Mikesch JH. et al., 2007, Cell Oncol. 28: 223-32.

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