Rat EGFR / HER1 / ErbB1 Protein (His Tag)

Produkt-Information von EGFR / HER1 / ErbB1 Protein

QC Testing von EGFR / HER1 / ErbB1 Protein

Purity	> 98 % as determined by SDS-PAGE	SDS-PAGE: EGFR protein
Bio-activity	1. Measured by its ability to bind recombinant human EGF-Fc (Cat:10605-H01H) in a functional ELISA. 2. Measured by its ability to bind recombinant mouse EGF-Fc (Cat:50482-M01H) in a functional ELISA.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 25
Molecular Mass	The recombinant rat EGFR comprises 633 amino acids and predicts a molecular mass of 70.7 kDa. The apparent molecular mass of  the recombinant protein is approximately 93-110 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EGFR / HER1 / ErbB1 Protein

Verwandte Produkte & Themen von EGFR / HER1 / ErbB1 Protein

Cancer>>Cancer Stem Cell (CSC)>>EGFR/ErbB/HER1

Cancer>>Cancer Biomarkers>>EGFR/ErbB/HER1

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>EGFR/ErbB/HER1

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>EGFR/ErbB/HER1

Beschreibung von EGFR / HER1 / ErbB1 Protein

As a member of the epidermal growth factor receptor tyrosine kinases subfamily, EGF R is a type Ⅰ transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR signaling plays a crucial role in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR homo- or hetero- dimerization, initiates subsequent tyrosine autophosphorylation and various downstream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling has been shown to exert actions on carcinogenesis and disease progression, and thus EGFR was proposed as a target for cancer therapy currently.

References

1. Schlessinger J. 2000, Cell. 103: 211-25.
2. Giaccone G. 2005, Ann Onc. 16: 538-48.
3. Yarden Y. 2001, Nat Rev Mol Cell Biol. 2: 127-37.

Sino Biological Inc. liefert Rat EGFR / HER1 / ErbB1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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