Rat IFNG / Interferon Gamma Protein

Produkt-Information von IFNG / Interferon Gamma Protein

QC Testing von IFNG / Interferon Gamma Protein

Purity	> 92 % as determined by SDS-PAGE	SDS-PAGE: IFNG / Interferon Gamma protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 23
Molecular Mass	The secreted recombinant rat IFNG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 375 amino acids and predicts a molecular mass of 42.5 kDa. The apparent molecular mass of the rat IFNG/Fc monomer is approximately 52 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IFNG / Interferon Gamma Protein

Verwandte Produkte & Themen von IFNG / Interferon Gamma Protein

Cancer>>Angiogenesis>>Cytokines/Chemokines in Angiogenesis>>IFNGR1/CD119

Immunology>>Cytokine & Receptor>>Interleukin & Receptor >>IL-10/Interferon Family>>IFNGR1/CD119

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>>IFNGR1/CD119

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers>>IFNGR1/CD119

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>IFNGR1/CD119

Beschreibung von IFNG / Interferon Gamma Protein

The protein IFN-γR1 (IFNGR1) is the ligand-binding chain(alpha) of the high-affinity interferon gamma receptor complex which is a heterodimer of IFN-γ R1 (IFN-γ Rα) and IFN-γ R2 (IFN-γ Rβ). IFN-γ R1 is necessary and sufficient for IFN-γ binding and receptor internalization, whereas IFN-γ R2 is required for IFN-γ signal transduction, but does not bind IFN-γ by itself. IFN-γ R1 is constitutively expressed in most cell types and soluble IFN-γ R1 has been detected in biological fluids. Human IFN-γ R1 cDNA encodes a 499 aa residue protein consisting of a 17 aa signal peptide, a 228 aa extracellular domain, a 23 aa transmembrane domain, and a 221 aa intracellular domain. Upon binding to IFN-γ receptor via its C-terminus, the type II interferon IFN gamma triggers multiple intracellular signalling processes including prevention of viral replication, inhibition of cell growth, modulation of cell differentiation, and induction of growth arrest at mid-G1 in different mammary carcinoma cell lines. A genetic variation or deficiency in IFN-γR1 is associated with susceptibility to Helicobacter pylori infection or mycobacterial disease.

References

1. Greenlund AC. et al., 1994, EMBO J. 13: 1591-600.
2. Bach EA. et al., 1997, Annu Rev Immunol. 15: 563-91.
3. Szente BE. et al., 1994, Biochem Biophys Res Commun. 203: 1645-54.
4. Schroder K. et al., 2004, J Leukoc Biol. 75:163-89.

Sino Biological Inc. liefert Rat IFNG / Interferon Gamma Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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