Rat EDA2R / TNFRSF27 Protein

Produkt-Information von EDA2R / TNFRSF27 Protein

QC Testing von EDA2R / TNFRSF27 Protein

Purity	>94% as determined by SDS-PAGE	SDS-PAGE: EDA2R / TNFRSF27 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met 2
Molecular Mass	The recombinant rat EDA2R/Fc is a disulfide-linked homodimer. The reduced monomer comprises 377 amino acids and has a predicted molecular mass of 42.3 kDa. The apparent molecular mass of the protein is approximately 51 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von EDA2R / TNFRSF27 Protein

Verwandte Produkte & Themen von EDA2R / TNFRSF27 Protein

Immunology>>Cytokine & Receptor>>TNF Superfamily>>XEDAR/EDA2R/TNFRSF27

Beschreibung von EDA2R / TNFRSF27 Protein

Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

References

1. Yan M. et al., 2000,Science. 290: 523-7.
2. Sinha SK. et al., 2002, J Biol Chem. 277: 44953-61.
3. Prodi DA. et al., 2008, J Invest Dermatol. 128 (9):2268-70.

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