Rat IL2RG / CD132 Protein

Produkt-Information von IL2RG / CD132 Protein

QC Testing von IL2RG / CD132 Protein

Purity	> 65 % as determined by SDS-PAGE	SDS-PAGE: IL2RG / CD132 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ser 25
Molecular Mass	The recombinant rat IL2RG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 479 amino acids and predicts a molecular mass of 55 kDa. The apparent molecular mass of  the recombinant protein is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL2RG / CD132 Protein

Verwandte Produkte & Themen von IL2RG / CD132 Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>CD132/IL2RG

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>CD132/IL2RG

Beschreibung von IL2RG / CD132 Protein

The interleukin 2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, which binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit which are members of the type I cytokine receptor family. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL-2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. It is proposed that the γ chain is common to the IL2, IL4, IL7, IL21 and probably also the IL13 receptors.

References

1. Robb RJ. et al., 1981, J Exp Med. 154 (5): 1455-74.
2. Leonard WJ. et al., 1982, Nature. 300 (5889): 267-9.
3. Sharon M. et al., 1986, Science. 234 (4778): 859-63.
4. Tsudo M. et al., 1987, Proc Natl Acad Sci. 84 (12): 4215-8.
5. Takeshita T. et al., 1992, J Immunol. 148 (7): 2154-8.
6. Johnson K. et al., 1994, Eur Cytokine Netw. 5 (1): 23-34.

Sino Biological Inc. liefert Rat IL2RG / CD132 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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