Rat IFNA4 / IFNα4 / Interferon alpha-4 Protein

Sino Biological Inc. liefert Rat IFNA4 / IFNα4 / Interferon alpha-4 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat IFNA4 / IFNα4 / Interferon alpha-4 Protein lesen Sie bitte: http://www.sinobiological.com/IFNA4-IFNα4-Interferon-alpha-4-Protein-g-9886.html

Produkt-Information von IFNA4 / IFNα4 / Interferon alpha-4 Protein

QC Testing von IFNA4 / IFNα4 / Interferon alpha-4 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: IFNA4 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant rat IFNA4 comprises 426 amino acids and predicts a molecular mass of 47.5 kDa. The apparent molecular mass of  the recombinant protein is approximately 48 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IFNA4 / IFNα4 / Interferon alpha-4 Protein

Verwandte Produkte & Themen von IFNA4 / IFNα4 / Interferon alpha-4 Protein

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>IL-10/Interferon Family>>IFNA4

Beschreibung von IFNA4 / IFNα4 / Interferon alpha-4 Protein

Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily, and are produced by a wide variety of cells types in response to challenges by foreign agents such as viruses, parasites and tumor cells. There are three major classes of IFNs according to the receptor type through which they signal, and the type I IFNs bind to a specific receptor complex known as the IFN-α receptor (IFNAR) consisting of IFNAR1 and IFNAR2 chains. The type I IFNs present in humans are IFN-α, IFN-β and IFN-ω, and the IFN-α come in 13 subtypes whose encoding genes locate in a cluster on chromosome 9. IFN-α is produced by leukocytes and mainly involved in innate immune response against viral infection together with other IFNs. IFN-α is produced in response to the presence of dsRNA, a key indicator of viral infection via Toll Like Receptors, and assists the immune response by inhibiting viral replication within host cells, activating natural killer cells and macrophages, increasing antigen presentation to lymphocytes, and inducing the resistance of host cells to viral infection. IFN-α also acts as a pyrogenic factor and thus causes fever by binding to opioid receptors and eliciting the release of prostaglandin-E2, and serves as an analgesic by employing the similar mechanism. Furthermore, IFN-α is suggested to promote apoptosis and accordingly has therapeutic effect against certain cancers by inducing increased production of the p53 gene product. Here, the IFN-α4a is an isoform of the human IFNA4 subtype.

References

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