Rat CEACAM1 / CD66a Protein (His Tag)

Sino Biological Inc. liefert Rat CEACAM1 / CD66a Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CEACAM1 / CD66a Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/CEACAM1-CD66a-Protein-g-10269.html

Produkt-Information von CEACAM1 / CD66a Protein

QC Testing von CEACAM1 / CD66a Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: CEACAM1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 35
Molecular Mass	The recombinant rat CEACAM1 comprises 399 amino acids and predicts a molecular mass of 44.9 kDa. The apparent molecular mass of  the recombinant protein is approximately 66-76 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CEACAM1 / CD66a Protein

Verwandte Produkte & Themen von CEACAM1 / CD66a Protein

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CEACAM1/CD66a

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CEACAM1/CD66a

Cancer>>Cancer Biomarkers>>CEACAM1/CD66a

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM) >>CEACAM1/CD66a

Immunology>>Cluster of Differentiation>>Granulocyte CD Antigen>>Granulocyte Markers>>CEACAM1/CD66a

Beschreibung von CEACAM1 / CD66a Protein

Carcinoembryonic antigen (CEA)-related cell adhesion molecule 1 (CEACAM1), also known as biliary glycoprotein I (BGP I) and CD66a, is a member of the carcinoembryonic antigen (CEA) gene family which belongs to the immunoglobulin superfamily. There are two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, and seven CEACAM has been identified in humans including type I  transmembrane proteins (CEACAM-1, CEACAM-3, CEACAM-4) and GPI-linked molecules (CEACAM-5, CEACAM-8). The highly glycosylated CEACAM1 contains one N-terminal V-type I g-like domain and three C2-type I g-like domains within its ECD, and one ITIM motif and a calmodulin binding site in the cytoplasmic region. It was described as an adhesion molecule mediating cell adhesion via both homophilic and heterophilic manners, and was detected on leukocytes, epithelia, and endothelia. Studies have revealed that CEACAM1 performs actions in multiple cellular processes including tissue differentiation, angiogenesis, apoptosis, metastasis, as well as the modulation of innate and adaptive immune responses.

References

1. Hinoda Y. et al., 1988, Proc Natl Acad Sci. 85: 6959-63.
2. Zalzali H. et al., 2008, Oncogene. 27: 7131-8.
3. Erqun S. et al., 2000, Mol Cell. 5: 311-20.
4. Oliveira-Ferrer L. et al., 2004, Cancer Res. 64: 8932-8.