Rat CD30 Ligand / TNFSF8 Protein

04.01.2013

Sino Biological Inc. liefert Rat CD30 Ligand / TNFSF8 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CD30 Ligand / TNFSF8 Protein lesen Sie bitte: http://www.sinobiological.com/CD30-Ligand-TNFSF8-Protein-g-10268.html

Produkt-Information von CD30 Ligand / TNFSF8 Protein

Synonym	TNFSF8
Protein Construction	A DNA sequence encoding the ratTNFSF8(Gln66-Asp237) was expressed with Fc region of human IgG1 at the N-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von CD30 Ligand / TNFSF8 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: CD30 Ligand protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant rat TNFSF8 comprises 432 amino acids and predicts a molecular mass of 47.9 kDa. The apparent molecular mass of the recombinant protein is approximately 58 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD30 Ligand / TNFSF8 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von CD30 Ligand / TNFSF8 Protein

Related Areas:

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD153/CD30L/TNFSF8

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>CD153/CD30L/TNFSF8

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD153/CD30L/TNFSF8

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Other>>CD153/CD30L/TNFSF8

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>>CD153/CD30L/TNFSF8

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells>>CD153/CD30L/TNFSF8

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
CD153/CD30L/TNFSF8	Human	CD153/CD30L/TNFSF8/Fc Protien, Recombinant	10040-H01H
CD153/CD30L/TNFSF8	Rat	CD30 Ligand / TNFSF8 Protein, Recombinant	80148-R01H

Antibodies:

Beschreibung von CD30 Ligand / TNFSF8 Protein

CD30 ligand (CD30L), also known as CD153 and TNFSF8, is a cytokine belonging to the emerging tumor necrosis factor (TNF) ligand superfamily, and is a specific ligand for CD30/ TNFRSF8 originally described as a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. CD30L is a type-II membrane glycoprotein expressed on activated T cells, stimulated monocyte-macrophages, granulocytes, eosinophils, and some Burkitt-like lymphoma cell lines. CD30L is capable of transducing signals through CD30 on different CD30+ lymphoma cell lines, and mediates pleiotropic biologic effects including cell proliferation, activation, differentiation, as well as cell death by apoptosis. CD30-CD30 ligand interaction has been suggested to have a pathophysiologic role in malignant lymphomas, particularly Hodgkin disease, large cell anaplastic lymphomas and Burkitt lymphomas, and is also involved in activation and functioning of the T cell-dependent immune response.

References

Gruss HJ. et al.,1994, Blood. 83: 2045-56.
Croager EJ. et al., 1997, Biochim Biophys Acta 1353: 231-5.
Wendtner CM. et al., 1995, Cancer Res. 55: 4157-61.
Fischer M. et al., 2006, J Clin Invest. 116: 2748-56.
Blazar BR. et al., 2004, J Immunol. 173: 2933-41.