Rat KIRREL3 / NEPH2 Protein (His Tag)

Sino Biological Inc. liefert Rat KIRREL3 / NEPH2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von KIRREL3 / NEPH2 Protein

QC Testing von KIRREL3 / NEPH2 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: KIRREL3 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 22
Molecular Mass	The recombinant rat KIRREL3 comprises 513 amino acids and predicts a molecular mass of 56.4 kDa. The apparent molecular mass of  the recombinant protein is approximately 60-64 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von KIRREL3 / NEPH2 Protein

Verwandte Produkte & Themen von KIRREL3 / NEPH2 Protein

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>KIRREL3/NEPH2

Beschreibung von KIRREL3 / NEPH2 Protein

Kin of IRRE-like protein 3, also known as Kin of irregular chiasm-like protein 3, Nephrin-like protein 2 and KIRREL3, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. KIRREL3 contains five Ig-like C2-type ( immunoglobulin-like ) domains. KIRREL3 is expressed in fetal and adult brain. It is also expressed in kidney, specifically in podocytes of kidney glomeruli. KIRREL3 could be involved in the hematopoetic supportive capacity of stroma cells. KIRREL3 might play a role in the axonal pathfinding, cell recognition, and synapse formation of DRG neurons on appropriate target cells, including the targeting of proprioceptive neurons on muscle spindles through the interaction with nephrin. Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4) which is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental perio.

References

1. Sellin L. et al., 2003, FASEB J. 17: 115-117.
2. Komori T. et al., 2008, J Comp Neurol. 511 (1): 92-108.
3. Bhalla K. et al., 2008, Am. J. Hum. Genet. 83: 703-713.