Rat CDH17 / Cadherin-17 / LI-cadherin Protein (His Tag)

Produkt-Information von CDH17 / Cadherin-17 / LI-cadherin Protein

QC Testing von CDH17 / Cadherin-17 / LI-cadherin Protein

Purity	> 81 % as determined by SDS-PAGE	SDS-PAGE: CDH17 / Cadherin-17 / LI-cadherin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 22
Molecular Mass	The recombinant rat CDH17 comprises 776 amino acids and predicts a molecular mass of 86.4 kDa. The apparent molecular mass of  the recombinant protein is approximately 118 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CDH17 / Cadherin-17 / LI-cadherin Protein

Verwandte Produkte & Themen von CDH17 / Cadherin-17 / LI-cadherin Protein

Immunology>>Adhesion Molecule>>Cadherin>>Cadherin-17/LI-cadherin

Beschreibung von CDH17 / Cadherin-17 / LI-cadherin Protein

Cadherins ( Calcium dependent adhesion molecules ) are a class of transmembrane proteins. They play important roles in cell adhesion, ensuring that cells within tissues are bound together. They are dependent on calcium ( Ca2+ ) ions to function. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I  cadherins. It has been observed that cells containing a specific cadherin subtype tend to cluster together to the exclusion of other types, both in cell culture and during development.
Cadherin-17, also known as Intestinal peptide-associated transporter HPT-1, Liver-intestine cadherin, LI-cadherin and CDH17, is a single-pass type I  membrane protein which contains 7 cadherin domains. Cadherin-17 / CDH17 is expressed in the gastrointestinal tract and pancreatic duct. It is not detected in kidney, lung, liver, brain, adrenal gland and skin. The expression of Cadherin-17 / CDH17 is characteristic of the advanced gastric carcinoma that is associated with poor prognosis. Cadherin-17 / CDH17 is a structurally unique member of the cadherin superfamily.

References

1. Angst B. et al., 2001, J Cell Sci. 114 (4): 629-41.
2. Horsfield J. et al., 2002,Mech Dev. 115 (1-2): 15-26.
3. Duguay D. et al., 2003, Dev Biol. 253: 309-23.
4. Ito R.?et al., 2005, Virchows Arch. 447 (4): 717-22.
5. Bayas MV. et al., 2005, Biophysical Journal.?90?(4): 1385.
6. Crosby CV. et al., 2005, Blood. 105 (7): 2771-6.
7. Hulpiau P. et al., 2009, Int J Biochem Cell Biol. 41 (2): 349-69.

Sino Biological Inc. liefert Rat CDH17 / Cadherin-17 / LI-cadherin Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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