Rat CDH15 / Cadherin-15 Protein

21.09.2012

Produkt-Information von CDH15 / Cadherin-15 Protein

Synonym	CDH15
Protein Construction	A DNA sequence encoding the rat CDH15 (Q75NI5) (Met1-Gly602) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von CDH15 / Cadherin-15 Protein

Purity	>92 % as determined by SDS-PAGE	SDS-PAGE: CDH15 / Cadherin-15 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Val 22
Molecular Mass	The recombinant rat CDH15 /Fc comprises 822 amino acids and has a predicted molecular mass of 90.6 kDa. The apparent molecular mass of the protein is approximately 118 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CDH15 / Cadherin-15 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CDH15 / Cadherin-15 Protein

Cadherin-15, also known as CDH15, belongs to the cadherin superfamily. Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from Cadherin-15 are expressed in myoblasts and upregulated in myotubule-forming cells. Cadherin-15 is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation. Defects in CDH3 are the cause of ectodermal dysplasia with ectrodactyly and macular dystrophy (EEM), also known as EEM syndrome, Albrectsen-Svendsen syndrome or Ohdo-Hirayama-Terawaki syndrome.

References

Shibata T. et al., 1997, J Biol Chem. 272 (8): 5236-40.
Bornemann A. et al.,1994, Anat Rec. 239 (2): 119-25.
Donalies M. et al., 1991, Proc Natl Acad Sci. 88 (18): 8024-8.

Sino Biological Inc. liefert Rat CDH15 / Cadherin-15 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CDH15 / Cadherin-15 Protein lesen Sie bitte: http://www.sinobiological.com/CDH15-Cadherin-15-Protein-g-9301.html