Rat NTRK2 / TrkB Protein

Produkt-Information von NTRK2 / TrkB Protein

QC Testing von NTRK2 / TrkB Protein

Purity	>92 % as determined by SDS-PAGE	SDS-PAGE: NTRK2 / TrkB protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Cys 32
Molecular Mass	The recombinant Rat NTRK2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 639 amino acids and has a predicted molecular mass of 71.5 kDa. The apparent molecular mass of the protein is approximately 120 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von NTRK2 / TrkB Protein

Verwandte Produkte & Themen von NTRK2 / TrkB Protein

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkB/NTRK2

Neuroscience>>Neurotrophic Factor & Receptor>>Neurotrophin & Receptor>>TrkB/NTRK2

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>>TrkB/NTRK2

Cancer>>Growth Factor & Receptor>> Neurotrophin & Receptor>>TrkB/NTRK2

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>>TrkB/NTRK2

Beschreibung von NTRK2 / TrkB Protein

TrkB is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor exclusively expressed in neurons of the central nervous system. BDNF( brain-derived neurotrophic factor ) exerts biological actions through its physiological receptor TrkB which leads to the initiation of intracellular signaling cascades and different biological responses in neurons. TRKB has two distinct binding regions for BDNF within the extracellular domain with high affinity. Upon neurotrophin binding, TrkB phosphorylates itself and the downstream molecular members of the related signal pathways. TrkB has been shown to play an important role in tumorigenesis and metastasis, and mutations in this gene are associated with obesity and mood disorders. Accordingly, BDNF/TrkB signaling is thought to be a potential therapeutic target for schizophrenia.

References

1. Klein R. et al., 1990, Cell. 64: 647-56.
2. Haniu M. et al., 1997, J Biol Chem. 272: 25296-303.
3. Haapasalo A. et al., 2002, J Biol Chem. 277: 43160-7.
4. Pillai A. 2008, Neurosignals. 16: 183-93.
5. Mas R. et al., 2007, Cancer Res. 67: 6221-9.

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