Rat CD34 Protein

Sino Biological Inc. liefert Rat CD34 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat CD34 Protein lesen Sie bitte: http://www.sinobiological.com/CD34-Protein-g-9890.html

Produkt-Information von CD34 Protein

QC Testing von CD34 Protein

Purity	> 80% as determined by SDS-PAGE	SDS-PAGE: CD34 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 37
Molecular Mass	The recombinant rat CD34/Fc is a disulfide-linked homodimer. The reduced monomer comprises 496 amino acids and has a predicted molecular mass of 54.5 kDa. The apparent molecular mass of the protein is approximately 112 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD34 Protein

Verwandte Produkte & Themen von CD34 Protein

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD34

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hematopoietic Stem Cell Marker>>CD34

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>CD34

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>CD34

Cancer>>Cancer Stem Cell (CSC)>>CD34

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>CD34

Immunology>>Cluster of Differentiation>>Hematopoietic Stem Cell CD Marker>>CD34

Beschreibung von CD34 Protein

CD34 molecule is a member of a family of single-pass transmembrane sialomucin proteins, and is selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. As a monomeric cell surface antigen, CD34 is highly glycosylated with nine potential N-linked and numerous potential O-linked glycosylation sites in its extracellular domain. Although used clinically in hematopoietic stem cell transplantation for more than 15 years, little is known about the exact function of CD34. It may act as an adhesion molecule in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells, and is also required for T cells to enter lymph nodes via interaction with L-selectin. It was indicated that CD34 is a phosphorylation target for activated PKC, and couples to the hematopoietic adapter protein CrkL, which were involved in CD34 signaling pathways. CD34 is abberantly expressed in many kinds of tumors and is implicated in leukemogenesis.

References

1. Fackler MJ. et al., 1990, J Biol Chem. 265: 11056-61.
2. Simmons DL. et al., 1992, J Immunol. 148: 267-71.
3. Latailade JJ. et al., 2000, Blood. 95: 756-68.
4. Furness SG. et al., 2006, Immunol Res. 34: 13-32.