Rat CD59 / CD59A / MAC-IP Protein

Sino Biological Inc. liefert Rat CD59 / CD59A / MAC-IP Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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Produkt-Information von CD59 / CD59A / MAC-IP Protein

QC Testing von CD59 / CD59A / MAC-IP Protein

Purity	> (55.3+31.4)% as determined by SDS-PAGE	SDS-PAGE: CD59 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 23
Molecular Mass	The recombinant rat CD59 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 319 amino acids and has a predicted molecular mass of 35.8 kDa. The apparent molecular mass of the protein is approximately 40 and 43 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD59 / CD59A / MAC-IP Protein

Verwandte Produkte & Themen von CD59 / CD59A / MAC-IP Protein

Immunology>>Innate Immunity>>Complement System>>CD59

Immunology>>Cluster of Differentiation>>CD59

Beschreibung von CD59 / CD59A / MAC-IP Protein

CD59 glycoprotein, also known as 20 kDa homologous restriction factor, HRF20, MAC-inhibitory protein, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIC11, MIRL and CD59, is a cell membrane protein which contains one UPAR/Ly6 domain. CD59 is a small, highly glycosylated, GPI-linked protein, with a wide expression profile. The soluble form of CD59 from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

References

1. Fletcher CM. et al., 1994, Structure. 2: 185-99.
2. Rudd PM. et al., 1997, J Biol Chem. 272: 7229-44.
3. Kimberley FC. et al., 2007, Mol Immunol. 44 (1-3): 73-81.
4. Gong Y. et al., 2007, Sci China C Life Sci. 50 (6): 773-9.
5. Picariello G. et al., 2008, Proteomics 8: 3833-47.
6. Heibeck TH. et al., 2009, J Proteome Res. 8: 3852-61.