Rat TNFRSF5 / CD40 Protein

Sino Biological Inc. liefert Rat TNFRSF5 / CD40 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat TNFRSF5 / CD40 Protein lesen Sie bitte: http://www.sinobiological.com/TNFRSF5-CD40-Protein-g-9948.html

Produkt-Information von TNFRSF5 / CD40 Protein

QC Testing von TNFRSF5 / CD40 Protein

Purity	> 95% as determined by SDS-PAGE	SDS-PAGE: TNFRSF5 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Leu 20
Molecular Mass	The recombinant rat CD40/Fc is a disulfide-linked homodimer. The reduced monomer comprises 415 amino acids and has a predicted molecular mass of 46.2 kDa. The apparent molecular mass of the protein is approximately 53 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von TNFRSF5 / CD40 Protein

Verwandte Produkte & Themen von TNFRSF5 / CD40 Protein

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD40/TNFRSF5

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD40/TNFRSF5

Immunology>>Cluster of Differentiation>>B Cell CD Antigen>> CD40/TNFRSF5

Immunology>>Cluster of Differentiation>>Monocyte/Macrophage CD Antigen>>Macrophage Markers / Monocyte Markers>>CD40/TNFRSF5

Immunology>>Cluster of Differentiation>>Natural Killer (NK) Cell CD Antigen>> CD40/TNFRSF5

Beschreibung von TNFRSF5 / CD40 Protein

CD40, also known as Tumor necrosis factor receptor superfamily member 5 ( TNFRSF5 ), is a member of the TNF-receptor superfamily. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. CD40 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The binding of CD154 ( CD40L ) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. AT-hook transcription factor AKNA is thought to coordinately regulate the expression of CD40 and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with CD40 and serves as a mediator of the signal transduction. The interaction of CD40 and its ligand CD154 is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. In the macrophage, the secondary signal is CD40L on the T cell which binds CD40 on the macrophage cell surface. As a result, the macrophage expresses more CD40 and TNF receptors on its surface which helps increase the level of activation.

References

1. McWhirter SM. et al., 1999, Proc Natl Acad Sci. 96 (15): 8408-13.
2. Tsukamoto N. et al., 1999, Proc Natl Acad Sci. 96 (4): 1234-9.
3. Ni CZ. et al., 2000, Proc. Natl Acad Sci. 97 (19): 10395-9.
4. Pype S. et al., 2000, J Biol Chem. 275 (24): 18586-93.
5. Contin C. et al., 2004, Néphrologie. 25 (4): 119-26.