Rat JAM-2 / JAM-B Protein

22.11.2012

Sino Biological Inc. liefert Rat JAM-2 / JAM-B Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Rat JAM-2 / JAM-B Protein lesen Sie bitte: http://www.sinobiological.com/JAM-2-JAM-B-Protein-g-9898.html

Product Information von JAM-2 / JAM-B Protein

Synonym	JAM2
Protein Construction	A DNA sequence encoding the rat JAM2 (Q3MHC0)(Met1-Asn236) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Source	Rat
Expression Host	Human Cells

QC Testing von JAM-2 / JAM-B Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: JAM-2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Phe 29
Molecular Mass	The recombinant rat JAM2/Fc is a disulfide-linked homodimer. The reduced monomer comprises 449 amino acids and has a predicted molecular mass of 50.3 kDa. The apparent molecular mass of the protein is approximately 61 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von JAM-2 / JAM-B Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Verwandte Produkte & Themen von JAM-2 / JAM-B Protein

Related Areas:

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>JAM-B/JAM2/VE-JAM/CD322

Immunology>>Adhesion Molecule>>Cell Adhesion Molecule (IgSF CAM)>>JAM-B/JAM2/VE-JAM/CD322

Immunology>>Cluster of Differentiation>>JAM-B/JAM2/VE-JAM/CD322

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM/Fc Protein, Recombinant	50464-M02H
JAM-B/JAM2/VE-JAM	Mouse	JAM-B/JAM2/VE-JAM Protein, Recombinant	50464-M08H
JAM-B/JAM2/VE-JAM	Rat	JAM-2 / JAM-B Protein, Recombinant	80376-R02H
JAM-B/JAM2/VE-JAM	Rat	JAM-2 / JAM-B Protein, Recombinant	80376-R08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Mouse JAM-B/JAM2/VE-JAM	WB, ELISA	JAM-2 / JAM-B Antibody	50464-RP01
Mouse JAM-B/JAM2/VE-JAM	WB, ELISA	JAM-2 / JAM-B Antibody (Antigen Affinity Purified)	50464-RP02

Beschreibung von JAM-2 / JAM-B Protein

Junctional adhesion molecule B, also known as Junctional adhesion molecule 2, Vascular endothelial junction-associated molecule, CD322 and JAM2, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily. JAM2 contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. JAM2 is prominently expressed on high endothelial venules. It is also present on the endothelia of other vessels. JAM2 is Localized to the intercellular boundaries of high endothelial cells. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. JAM2 is localized in the tight junctions between high endothelial cells. JAM2 acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs. Mouse JAM2 may play a role in the processes of lymphocyte homing to secondary lymphoid organs.

References

Cunningham SA. et al., 2000, J Biol Chem. 275: 34750-6.
Gardiner K. et al., 2002,Genomics. 79: 833-43.
Ota T. et al., 2004, Nat Genet. 36 :40-5.
Zhang Z. et al., 2004, Protein Sci. 13: 2819-24.