Rat B2M / Beta-2-microglobulin Protein (His Tag)

Produkt-Information von B2M / beta-2 microglobulin Protein

QC Testing von B2M / beta-2 microglobulin Protein

Purity	> 97 % as determined by SDS-PAGE	SDS-PAGE: beta-2 microglobulin protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Ile 21
Molecular Mass	The secreted recombinant rat B2M comprises 110 amino acids and predicts a molecular mass of 13 kDa. The apparent molecular mass of the rat B2M is approximately 15 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von B2M / beta-2 microglobulin Protein

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Immunology>>Adaptive Immunity>>Major Histocompatibility Complex>>B2M/beta-2 microglobulin

Beschreibung von B2M / beta-2 microglobulin Protein

Beta-2-microglobulin, also known as B2M, is a secreted protein which belongs to thebeta-2-microglobulin family. It contains oneIg-like C1-type (immunoglobulin-like) domain. Beta-2 microglobulin (B2M) plays a pivotal role in the biology of mammals, including its association with major histocompatibility complex (MHC) Class I gene products. The latter molecules have been shown to affect reproduction in both mice and humans. B2M forms the small invariable light chain subunit of class I HLA antigens on the cell membrane of all nucleated cells. During the continuous turnover of the HLA molecules. B2M is shed from the cell membrane into blood. Lymphocytes are the main source of serum free B2M. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. In lymphatic malignancies serum B2M has significant prognostic value. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

References

1. Miyata T. et al.,1994 Biochemistry. 33: 12215-21.
2. Remes,K. et al.,1996, Leuk Lymphoma. 21 (3-4): 233-8.
3. Trinh CH. et al., 2002, Proc Natl Acad Sci. 99: 9771-6.
4. He XH. et al., 2004, Sheng Wu Gong Cheng Xue Bao. 20: 99-103.
5. Kihara M. et al., 2006, J Biol Chem. 281: 31061-9.
6. Ricagno S. et al., 2009, Biochem Biophys Res Commun. 380: 543-7.

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