Mouse CD40L / CD154 / TNFSF5 Protein

Produkt-Information von CD40L / CD154 / TNFSF5 Protein

QC Testing von CD40L / CD154 / TNFSF5 Protein

Purity	> 80 % as determined by SDS-PAGE	SDS-PAGE: CD40L/CD154/TNFSF5 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu
Molecular Mass	The recombinant mouse CD40LG/Fc is a disulfide-linked homodimer. The reduced monomer comprises 406 amino acids and has a calculated molecular mass of 44.4 kDa. The apparent molecular mass of the monomer is approximately 50 kDa in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CD40L / CD154 / TNFSF5 Protein

Verwandte Produkte & Themen von CD40L / CD154 / TNFSF5 Protein

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>CD40L/CD154/TNFSF5

Immunology>>Adaptive Immunity>>T Cell>>Regulatory T Cell>>CD40L/CD154/TNFSF5

Immunology>>Cytokine & Receptor>>TNF Superfamily>>CD40L/CD154/TNFSF5

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>Helper T Cells / Regulatory T Cells>>CD40L/CD154/TNFSF5

Beschreibung von CD40L / CD154 / TNFSF5 Protein

CD40 ligand, also known as CD40-L, T-cell antigen Gp39, TNF-related activation protein, Tumor necrosis factor ligand superfamily member 5, CD154, CD40L and TNFSF5, is a single-pass type II membrane protein which belongs to the tumor necrosis factor family. CD40L ( CD154 / TNFSF5 ) is specifically expressed on activated CD4+ T-lymphocytes. The soluble form of CD40L ( CD154 / TNFSF5 ) is derived from the membrane form by proteolytic processing. N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway. CD40L ( CD154 / TNFSF5 ) mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. It is involved in immunoglobulin class switching. Defects in CD40L are the cause of X-linked immunodeficiency with hyper-IgM type 1 (HIGM1), also known as X-linked hyper IgM syndrome (XHIM). It is an immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes.

References

1. Korthaeuer U. et al., 1993, Nature. 361: 539-41.
2. Lin Q. et al., 1996, J Clin Invest. 97: 196-201.
3. Seyama K. et al.,1998, Blood. 92: 2421-34.
4. Khandekar SS. et al., 2001, Protein Expr Purif. 23: 301-10.
5. Furman MI. et al., 2004, J Am Coll Cardiol. 43: 2319-25.

Sino Biological Inc. liefert Mouse CD40L / CD154 / TNFSF5 Protein mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse CD40L / CD154 / TNFSF5 Protein lesen Sie bitte: http://www.sinobiological.com/CD40L-CD154-TNFSF5-Protein-g-8870.html