Canine IL4 / Interleukin-4 Protein (Native)

Produkt-Information von IL4 / Interleukin-4 Protein

QC Testing von IL4 / Interleukin-4 Protein

Purity	> 96 % as determined by SDS-PAGE	SDS-PAGE: IL4 / Interleukin-4 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant canine IL4 consists of 109 amino acids and has a calculated molecular mass of 13 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 12-14 KDa band.
Formulation	Lyophilized from 0.2μm filtered solution of PBS, PH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von IL4 / Interleukin-4 Protein

Verwandte Produkte & Themen von IL4 / Interleukin-4 Protein

Immunology>>Adaptive Immunity>>B Cell>>IL-4/IL4

Immunology>>Adaptive Immunity>>T Cell>>Helper T Cell>>IL-4/IL4

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>IL-4/IL4

Beschreibung von IL4 / Interleukin-4 Protein

Interleukin-4, also known as B-cell stimulatory factor 1, BSF-1, Binetrakin, Lymphocyte stimulatory factor 1, pitrakinra and IL4, is a secreted protein which belongs to the?IL-4 / IL-13 family. Interleukin-4 / IL4 has many biological roles, including the stimulation of activated B-cell and T-cell proliferation, and the differentiation of CD4+ T-cells into Th2 cells. It is a key regulator in humoral and adaptive immunity. Interleukin-4 / IL4 participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. Interleukin-4 / IL4 also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Genetic variations in Interleukin-4 / IL4 may be a cause of susceptibility to ischemic stroke, also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

References

1. Powers R., et al., 1992, Science 256:1673-7.
2. Smith L.J.,?et al., 1992, J. Mol. Biol. 224:899-904.
3. Walter M.R., et al., 1992, J. Biol. Chem. 267:20371-6.
4. Mueller T., et al., 1994, J. Mol. Biol. 237:423-36.
5. Zee R.Y.L., et al., 2004, Hum. Mol. Genet. 13:389-96.

Sino Biological Inc. liefert Canine IL4 / Interleukin-4 Protein (Native) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

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