PTS / PTPS Protein (His Tag)

23.04.2013

Sino Biological Inc. liefert PTS / PTPS Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über PTS / PTPS Protein (His Tag)lesen Sie bitte: http://www.sinobiological.com/PTS-PTPS-Protein-Antibody-a-5864.html

Produkt-Information von PTS / PTPS Protein

Synonym	PTS
Protein Construction	A DNA sequence encoding the mature form of human PTS (Q03393) (Met1-Glu145) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von PTS / PTPS Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: PTS protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human PTS consists of 160 amino acids and predicts a molecular mass of 18.2 KDa. It migrates as an approximately 27 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, 40% Glycerol, pH, 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von PTS / PTPS Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PTS / PTPS Protein

PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. PTS is involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. PTS also catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A), also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet.

References

Ashida A. et al., 1994, Genomics. 24: 408-10.
Ashida A. et al., 1993, Biochem Biophys Res Commun. 195: 1386-93.
Thoeny B. et al., 1992, Biochem Biophys Res Commun. 189: 1437-43.

PTS related areas, pathways, and other information