SMNDC1 Protein (His Tag)

23.04.2013

Sino Biological Inc. liefert SMNDC1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über SMNDC1 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/SMNDC1-SPF30-Protein-Antibody-a-5867.html

Produkt-Information von SMNDC1 Protein

Synonym	SMNDC1, SMNR, SPF30
Protein Construction	A DNA sequence encoding the mature form of human SMNDC1 (O75940) (Met1-Gln238) was expressed with a polyhistide tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von SMNDC1 Protein

Purity	> 85% as determined by SDS-PAGE	SDS-PAGE: SMNDC1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human SMNDC1 consists of 253 amino acids and predicts a molecular mass of 28.5 KDa. It migrates as an approximately 29 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, 20% Glycerol, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von SMNDC1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von SMNDC1 Protein

SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. SMNDC1 is necessary for spliceosome assembly. Its overexpression causes apoptosis.

References

Rappsilber J. et al., 2001, J Biol Chem. 276 (33): 31142-50.
Talbot K. et al., 1999, Hum Mol Genet. 7 (13): 2149-56.
Neubauer G. et al., 1998, Nat Genet. 20 (1): 46-50.

SMNDC1 (SPF30) related areas, pathways, and other information