PTH2 / PTRH2 Protein (His Tag)

23.05.2013

Sino Biological Inc. liefert PTH2 / PTRH2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über PTH2 / PTRH2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/PTH2-PTRH2-Protein-g-11788.html

Produkt-Information von PTH2 / PTRH2 Protein

Synonym	PTRH2, BIT1, PTH2
Protein Construction	A DNA sequence encoding the human PTRH2 (Q9Y3E5) (Gly63-Tyr179) was expressed with a polyhistidine tag at the N-terminus.
Source	Human
Expression Host	E.coli

QC Testing von PTH2 / PTRH2 Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: PTH2 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	His
Molecular Mass	The recombinant human PTRH2 consists of 132 amino acids and predicts a molecular mass of 14.5 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 20mM Tris, 10% glycerol, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von PTH2 / PTRH2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PTH2 / PTRH2 Protein

PTH2, also known as PTRH2, is a mitochondrial protein which belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate for PTH 2 may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. When in the cytoplasm, PTRH2 regulates the function of 2 transcriptional regulators, TLE5 and TLE1, thus promoting caspase-independent cell death.

References

Prahalad AK. et al., 2006, Proteomics. 6 (12): 3482-93.
Jin L. et al., 2000, J Biol Chem. 275 (35): 27238-44.
Boone T. et al., 2000, Nat Struct Biol. 7 (6): 486-91.