Mouse FABP4 / ALBP / AFABP Protein (His Tag)

23.05.2013

Sino Biological Inc. liefert Mouse FABP4 / ALBP / AFABP Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über Mouse FABP4 / ALBP / AFABP Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/FABP4-ALBP-A-FABP-Protein-Antibody-a-1172.html

Produkt-Information von FABP4 / ALBP / AFABP Protein

Synonym	FABP4, Ap2
Protein Construction	A DNA sequence encoding the mouse FABP4 (NP_077717.1) (Cys2-Ala132) was expressed with a polyhistidine tag at the N-terminus.
Source	Mouse
Expression Host	E.coli

QC Testing von FABP4 / ALBP / AFABP Protein

Purity	> 95 % as determined by SDS-PAGE	SDS-PAGE: FABP4 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant mouse FABP4 consists of 138 amino acids and predicts a molecular mass of 15.5 KDa. It migrates as an approximately 15 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM tris, 0.2 M NaCl, pH 7.5. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von FABP4 / ALBP / AFABP Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von FABP4 / ALBP / AFABP Protein

Fatty acid-binding protein, adipocyte, also known as Adipocyte-type fatty acid-binding protein, Fatty acid-binding protein 4, Adipocyte lipid-binding protein, and FABP4, is a cytoplasm protein which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. In familial combined hyperlipidemia (FCHL), FABP4 correlated to body mass index (BMI), waist circumference, insulin levels, and homeostasis model assessment (HOMA) index.FABP4 levels were associated with triglyceride-rich lipoproteins independent of insulin resistance. FABP4 is an adipokine regulating systemic insulin sensitivity, lipid and glucose metabolism. In humans serum FABP4 levels correlate significantly with features of PCOS. It appears to be a determinant of atherogenic dyslipidemia. FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice. FABP4 concentration significantly increased with an increasing of MS features and was strongly correlated with body-mass index, triglycerides, HDL-cholesterol concentrations, insulin and blood pressure. Patients in the highest quartile of FABP4 presented a six-fold increased odds ratio for MS and a three-fold increased odds for LD, adjusted by age, sex, body-mass index and the antiretroviral therapy. FABP4 is a strong plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.

References

Van Dongen MJ. et al., 2002, J Am Chem Soc. 124 (40): 11874-80.
Coll B. et al., 2008, Atherosclerosis. 199 (1): 147-53.
Hoashi S. et al., 2008, BMC Genet. 9: 84.
Cai H. et al., 2010, Bioorg Med Chem Lett. 20 (12): 3675-9.