PPIL1 Protein (His Tag)

06.03.2013

Sino Biological Inc. liefert PPIL1 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über PPIL1 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/PPIL1-Protein-g-10545.html

Produkt-Information von PPIL1 Protein

Synonym	PPIL1, CYPL1
Protein Construction	A DNA sequence encoding the human PPIL1 (Q9Y3C6) (Met1-Gly166) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	E.coli

QC Testing von PPIL1 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: PPIL1 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Met
Molecular Mass	The recombinant human PPIL1 consists of 172 amino acids and predicts a molecular mass of 19.1 KDa. It migrates as an approximately 17 - 20 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile 50mM Tris, 10% glycerol, PH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von PPIL1 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PPIL1 Protein

PPIL1 is a member of the cyclophilin family. Cyclophilins are well conserved and ubiquitous. Members of cyclophilin family take an significant part in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. PPIL1 is a peptidylprolyl isomerase(PPIase). It increases the folding of proteins and catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. PPIL1 is involved in proliferation of cancer cells through modulation of phosphorylation of stathmin. It is a novel molecular target for colon-cancer therapy.

References

Xu C. et al., 2005, J Biomol NMR. 31 (2): 179-80.
Ozaki K. et al., 1997, Cytogenet Cell Genet. 72 (2-3): 242-5.
Mann SS. et al., 1999, Cytogenet Cell Genet. 83 (3-4): 228-9.