LILRB2 / ILT4 / LIR-2 Protein (His Tag)

06.03.2013

Sino Biological Inc. liefert LILRB2 / ILT4 / LIR-2 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über LILRB2 / ILT4 / LIR-2 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/LILRB2-ILT4-LIR-2-Protein-g-10544.html

Produkt-Information von LILRB2 / ILT4 / LIR-2 Protein

Synonym	LILRB2, ILT4, LIR2, MIR10
Protein Construction	A DNA sequence encoding the human LILRB2 (AAH36827.1) (Met1-Val461) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von LILRB2 / ILT4 / LIR-2 Protein

Purity	> 90% as determined by SDS-PAGE	SDS-PAGE: LILRB2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Gln 22
Molecular Mass	The recombinant human LILRB2 consists of 451 amino acids and predicts a molecular mass of 49.2 KDa. It migrates as an approximately 66 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von LILRB2 / ILT4 / LIR-2 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von LILRB2 / ILT4 / LIR-2 Protein

ILT4, also known as LILRB2, is a member of the the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.

References

Fanger NA. et al., 1998, Eur J Immunol. 28 (11): 3423-34.
Willcox BE. et al., 2003, BMC Struct Biol. 2: 6.
Chang CC. et al., 2002, Nat Immunol. 3 (3): 237-43.