PAX8 Protein (His Tag)

09.05.2013

Sino Biological Inc. liefert PAX8 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über PAX8 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/PAX8-Protein-Antibody-a-5916.html

Produkt-Information von PAX8 Protein

Synonym	PAX8
Protein Construction	A DNA sequence encoding the mature form of human PAX8 (Q06710-1) (Pro2-Ser146) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	E.coli

QC Testing von PAX8 Protein

Purity	> 90 % as determined by SDS-PAGE	SDS-PAGE: PAX8 protein
Endotoxin	Please contact us for more information.
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Pro 2
Molecular Mass	The recombinant human PAX8 consists of 152 amino acids and predicts a molecular mass of 16.9 KDa. It migrates as an approximately 16 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, 10% Glycerol, pH 8.0. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA. Please contact us for any concerns or special requirements.

Usage Guide von PAX8 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von PAX8 Protein

PAX8 gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain. PAX8 is involved in thyroid follicular cell development and expression of thyroid-specific genes. Also functions in very early stages of kidney organogenesis. Mutations in PAX8 gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

References

Poleev A. et al., 1995, Eur J Biochem. 228 (3): 899-911
Poleev A. et al., 1993, Development. 116 (3): 611-23.
Di Palma. et al., 2003, J Biol Chem. 278 (5): 3395-402.