CFHR2 / FHR2 / HFL3 Protein (His Tag)

27.11.2012

Sino Biological Inc. liefert CFHR2 / FHR2 / HFL3 Protein (His Tag) mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über CFHR2 / FHR2 / HFL3 Protein (His Tag) lesen Sie bitte: http://www.sinobiological.com/CFHR2-FHR2-HFL3-Protein-g-9917.html

Produkt-Information von CFHR2 / FHR2 / HFL3 Protein

Synonym	CFHR2
Protein Construction	A DNA sequence encoding the human CFHR2 (P36980-1) (Met1-Lys270) was expressed with a polyhistidine tag at the C-terminus.
Source	Human
Expression Host	Human Cells

QC Testing von CFHR2 / FHR2 / HFL3 Protein

Purity	> (46.1+ 45.6)% as determined by SDS-PAGE	SDS-PAGE: CFHR2 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Glu 19
Molecular Mass	The recombinant human CFHR2 consists of 263 amino acids and predicts a molecular mass of 30.2 KDa. It migrates as an approximately 31 and 35 KDa band in SDS-PAGE under reducing conditions.
Formulation	Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von CFHR2 / FHR2 / HFL3 Protein

Storage	Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution	A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Beschreibung von CFHR2 / FHR2 / HFL3 Protein

CFHR2 is a member of the complement factor H protein family. The human complement factor H protein family consists of the complement and immune regulators factor H, the factor H-like protein 1(FHL-1) and five factor H-related proteins (CFHR-1 to -5). Members of the H-related protein family are exclusively composed of individually folded protein domains, termed short consensus repeats (SCRs) or complement control modules. CFHR2 contains 4 Sushi (CCP/SCR) domains and is expressed by the liver and secreted in plasma. It was identified as novel ligands for both borrelial proteins by employing MALDI-TOF. CFHR2 is synthesized in the liver and secreted into plasma. It may be involved in complement regulation. CFHR2 can also be associated with lipoproteins and may play a role in lipid metabolism.

References

Skerka C. et al., 1991, J Biol Chem. 266 (18): 12015-20.
Díaz-Guillén MA. et al., 1999, Immunogenetics. 49 (6): 549-52.
Strausberg RL. et al., 2003, Proc Natl Acad Sci. 99 (26): 16899-903.