OSMR / IL-31RB Antikörper

16.08.2012

Produkt-Information von OSMR / IL-31RB Antikörper

Immunogen	Recombinant Mouse OSMR / IL-31RB protein (Catalog#50500-M08H)
Antibody Type	Rabbit Polyclonal Antibody ( Antibody Purification Platform )
Ig Type	Rabbit IgG
Formulation	0.2 μm filtered solution in PBS with 5% trehalose
Preparation	Produced in rabbits immunized with purified, recombinant Mouse OSMR / IL-31RB (rM OSMR / IL-31RB; Catalog#50500-M08H; O70458-1; Met 1-Leu 738). Total IgG was purified by Protein A affinity chromatography.

Usage Guide von OSMR / IL-31RB Antikörper

Specificity	Mouse OSMR / IL-31RB
Western blot	This antibody can be used at 1-2 μg/mL with the appropriate secondary reagents to detect Mouse OSMR in WB. Using a DAB detection system, the detection limit for Mouse OSMR is approximately 4 ng/lane under non-reducing conditions and 1 ng/lane under reducing conditions.
Direct ELISA	This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Mouse OSMR. The detection limit for Mouse OSMR is approximately 0.00975 ng/well.
Storage	This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Verwandte Produkte & Themen von OSMR / IL-31RB Antikörper

Related Areas:

Immunology>>Cytokine & Receptor>>Interleukin & Receptor>>Other>>OSMR/IL-31RB

Proteins:

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
OSMR/IL-31RB	Human	OSMR/IL-31RB Protein, Recombinant	11226-H08H
OSMR/IL-31RB	Mouse	OSMR/IL-31RB Protein, Recombinant	50500-M08H

Antibodies:

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human OSMR/IL-31RB	WB, ELISA	OSMR/IL-31RB Antibody, Mouse MAb	11226-MM01
Human OSMR/IL-31RB	WB, ELISA	Rabbit Polyclonal Antibody	11226-RP01
Human OSMR/IL-31RB	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	11226-RP02
Human OSMR/IL-31RB	WB, ELISA	OSMR / IL-31RB Antibody	11226-R007
Mouse OSMR/IL-31RB	WB, ELISA	OSMR / IL-31RB Antibody	50500-RP01

Hintergrund von OSMR / IL-31RB Antikörper

Oncostatin-M-specific receptor subunit beta, also known as interleukin-31 receptor subunit beta, and OSMR, is a single-pass type I membrane protein which belongs to thetype I cytokine receptor family and Type 2 subfamily. OSMR contains four fibronectin type-III domains and is expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines. Four forms of OSMR have been identified: leukemia inhibitory factor receptor (LIFR), OSMR beta, short-form OSMR (OSMRs) and soluble OSMR (sOSMR). OSMR associates with IL31RA to form the IL31 receptor. It binds IL31 to activate STAT3 and possibly STAT1 and STAT5. OSMR is part of a heterodimeric receptor complex that mediates signal transduction of the pleiotropic cytokine OSM via a signaling pathway involving Janus kinases (Jaks) and transcription factors of the signal transducers and activators of transcription (STAT) family. Defects in OSMR are the cause of amyloidosis type 9 (AMYL9) which is a hereditary primary amyloidosis characterized by localized cutaneous amyloid depositio.

References

Mosley B. et al., 1996, J. Biol. Chem. 271: 32635-32643.
Radtke, S. et al., 2002, J Biol Chem. 277 (13): 11297-305.
Morikawa, YJ. et al., 2004, Neurosci. 24 (8): 1941-7.
Dillon SR. et al., 2004, Nat. Immunol. 5: 752-760.
Chen, D. et al., 2008,J Pathol. 215 (3): 290-9.

Sino Biological Inc. liefert OSMR / IL-31RB Antikörper mit höherer Qualität und günstiger Kosten im Vergleich mit anderen globalen Lieferanten.

Weitere Informationen über OSMR / IL-31RB Antikörper lesen Sie bitte: http:www.sinobiological.com/OSMR-IL-31RB-Antibody-g-9283.html