NRG1 (aa 2-246) Protein

Produtk-Information von NRG1 Protein

QC Testing von NRG1 Protein

Purity	> 88 % as determined by SDS-PAGE	SDS-PAGE: NRG1 protein
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method
Stability	Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N terminal	Asp
Molecular Mass	The recombinant human NRG1/mFc comprises 481 amino acids and has a predicted molecular mass of 53.4 kDa. The apparent molecular mass of the monomer is approximately 67 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Formulation	Lyophilized from a 0.2μm filtered solution of PBS,pH7.4. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.

Usage Guide von NRG1 Protein

Verwandte Produkte & Themen von NRG1 Protein

Neuroscience>>Neurotrophic Factor & Receptor>>Other Neurotrophic Factors & Receptors>>NRG1

Beschreibung von NRG1 Protein

Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.

References

1. Nicodemus KK. et al., 2010, Arch Gen Psychiatry. 67 (10): 991-1001.
2. Tan W. et al., 2007, J Biol Chem. 282 (33): 24343-51.
3. Holmes WE. et al., 1992, Science. 256 (5060): 1205-10.

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